Welcome to the Ninth issue of The Alcoholism Guide newsletter.

September E-zine contents:

  1. Naltrexone,The Genetics Of Alcoholism And The Sinclair Method
  2. New Resources At The Alcoholism Guide
  3. New Pages On The Alcoholism Guide
  4. Alcoholism Stories And Questions
  5. Free E-report: AA Cracked

Naltrexone, The Genetics Of Alcoholism And The Sinclair Method

Laura Ray, director of UCLA Addictions Laboratory, is the lead author of new research (available in the online journal Neuropsychopharmacology) which has found that a particular gene mutation may well predict whether naltrexone medication is effective in an individual.

This gene, the OPRM1 gene, is present in all humans, however, not everybody has the "AG" or "GG" variants of OPRM1. Those that do have one of these variants can be expected to respond better to naltrexone than those who don't.

This gene variation is present in only 20% of Caucasians, 5% of African Americans but interestingly enough, in 50% of people of Asian descent.

Not only does this gene predict the efficacy of naltrexone but those with the variants are also more susceptible to the effects of alcohol reporting a 'better' high when they drink.

What I believe is of interest in this study is that the participants took the naltrexone BEFORE they drank (as in The Sinclair Method). Those with the gene variants reported getting a less intense high from the alcohol and reported other side effects that reduced their craving for alcohol.

The conclusions drawn by this research mirror those experiences reported by people attempting the Sinclair Method of alcoholism treatment in two ways:

  1. The Sinclair Method does not work for everyone. Some find it very effective at curtailing their alcohol consumption while others are less successful.
  2. Although Naltrexone is licensed by the FDA to be only prescribed to patients when they have already given up alcohol, it seems to be as effective, if not more so (at least for some), when used in conjunction with alcohol consumption.

What such studies represent is a move away from the spiritual treatment of alcoholism/addictions to a more targeted, science based approach that utilizes disciplines such as pharmacology, behavioral science and genetics in order to provide better outcomes for those struggling with alcohol dependency.

This is not to say there is no place for Alcoholics Anonymous and its ilk as such methods do have their merits, however, in isolation they are denying the complex character of alcoholism.

New Resources

I am now selling two e-books on The Alcoholism Guide. I am not the author of either, but have read and value both of them. There are a lot of exploitative, poorly researched and badly written e-books out there. These, however, are not. They will be of great benefit to visitors to the site.

What do you think? I would be very grateful if you would visit the sales pages for these resources and give me your opinion as to their relevance to site. If you have any comments about them, please contact me.

-How To Give Up Alcohol
This book is for those who want to either give up drinking altogether or cut down on their alcohol consumption. It starts by assessing your drinking problem and then helps you devise an action plan depending on your goal. It is full of charts and worksheets that give you the structure and motivation to quit or moderate your drinking. Included in the price are daily e-mails from the author (Rahul Nag) giving you support, encouragement and advice as you embark on your new life. Although on the pricey side, there is a 60 day no-quibble money back guarantee. Nothing to lose.

-Help Me! I'm In Love With An Addict
This book, obviously, is directed at those living with and/or loving an alcoholic. C-P Lehman has written a comprehensive guide to loving an addict that can help spouses and partners of alcoholics assess their lives and break the behavioral patterns that for so long have tied them to the woes and problems of their loved ones. A fantastic resource


I've added quite a number of pages this month on mixing medication with alcohol, scroll down and you'll find a short description of each and a link to the relevant page on The Alcoholism Guide Website.

I have also written an E-report called AA CRACKED which I have made available on the site. This report is an attempt to debunk the myths about Alcoholics Anonymous that contribute to it being regarded as the only viable alcoholism treatment option.

Here is the download link, please take a look at it, and if you have any comments please contact me. Also, if you think it may be of interest to anyone you know, pass it on. It is free to be used/distributed by anyone as long as its original form is kept.

New! Comments

Have your say about what you just read! Leave me a comment in the box below.

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Deborah Morrow, M.S. Addiction Psychology, is the director of treatment programs for The Alcoholism Guide website. In her practice Deborah provides on-line coaching and support for those dependent on alcohol or who require other services such as relapse prevention or court mandated services. (Read More)

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