Mixing Zoloft and Alcohol: Is It Dangerous?

Medically Reviewed By Kayla Loibl | Last Edited : November 26, 
2020 | 4 Sources

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 Mixing Zoloft and alcohol is not recommended 

Effects of Drinking Alcohol with Depression

To better understand the effects that drinking alcohol can have while a person is taking Zoloft, it is important to know the effects that drinking alcohol would have on a person who is struggling with depression.
For individuals who are not taking any psychotropic medications for depression, alcohol can have a significant impact on their mood, thoughts and behaviors.

Alcohol decreases activity in the part of our brain that is responsible for decision making and rational thinking. This change contributes to the rise of aggression often seen when a person is impaired.

Alcohol is also known to cause an increase in anxiety symptoms, irritability, feelings of worthlessness and tiredness.  This can lead to an increase in risk taking behaviors and putting oneself in dangerous situations.

 Uses for Zoloft

Zoloft has been a commonly used medication for over 25 years. It is also referred to by its generic name Sertraline. Zoloft is recognized as an antidepressant. Below are mental health issues that Zoloft is commonly prescribed for:

· Depression
· Panic disorder
· Obsessive-compulsive disorder
· Generalized anxiety disorder
· Post-traumatic stress disorder
· Premenstrual Dysphoric disorder
· Social Anxiety
· Impulse control disorders
· Phobias

As a selective serotonin reuptake inhibitor, Zoloft effectively retains sufficient amounts of serotonin in the brain rather than allowing receptors to essentially inhibit serotonin from circulating throughout the brain.
This continuous, rich supply of serotonin regulates mood as well as sleep, appetite and sexual drive.

Research has provided us with a better understanding of the potential side effects associated with Zoloft. According to their own website, common side effects experienced by adults who take Zoloft as prescribed are:

· nausea, loss of appetite, diarrhea, or indigestion
· increased sweating
· tremor or shaking
· agitation
· change in sleep habits including increased sleepiness or insomnia
· sexual problems including decreased libido and ejaculation failure
· feeling tired or fatigued
· anxiety

Common side effects experienced by children and adolescents who take Zoloft as prescribed are:

· abnormal increase in muscle movement or agitation
·  nose bleeds
·  urinary incontinence
·  aggressive reaction
·  possible slowed growth rate
·  and weight change

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Causes of Serotonin Imbalance

Researchers have yet to discover the cause of serotonin imbalance or other neurotransmitter imbalances occurring in the brain. However, results of studies have indicated that several factors play important roles in why an individual may suffer from depression and anxiety. 

Individual environmental, behavioral and cognitive reactions to life experiences seem to affect neurotransmitter actions, as well as the development or underdevelopment of coping skills.

Studies investigating the interaction of Zoloft and alcohol have revealed no pertinent or statistically significant results.

The Food and Drug Administration (FDA) currently recommends avoiding drinking alcohol while taking Zoloft. Empirical observations of individuals who take Zoloft and alcohol suggest that people who drink while taking this antidepressant experience:

•  Intensification of alcohol's effects on psycho-motor functions
•  Aggressiveness
• Increased depression and possible suicidal ideation
•  Exaggerated impulsiveness
•  Blackouts, if enough alcohol and Zoloft are ingested 

For chronic alcoholics who are recovering but suffer from sustained liver damage, having a less than optimally functioning liver may inhibit elimination of Zoloft which could cause subsequent toxic levels of Zoloft to accumulate in the body.

Individuals with impaired liver functioning usually need to take lower than normal doses of Zoloft while continuing to be monitored by their physician.

According to Suzanne LeVert, author of the book The Facts about Antidepressants (2006), alcohol appears to stimulate protein compounds that facilitate the breakdown of Zoloft in the bloodstream. This means that levels of Zoloft in the body are significantly lower than the prescribed level, which may possible worsen depression and anxiety symptoms.

The Central Nervous System, Zoloft and Alcohol

Alcohol, unlike Zoloft, depresses neurochemical processes in the brain which control thinking, muscle control and metabolism. Pharmacological medications often interact with ethanol which detrimentally exaggerate or minimize desired effects of the medication.

Drinking often exacerbates depression by temporarily anesthetizing neuronal activity in the brain. Once the effect wears off, the depression still exists and may even worsen, causing the person to reach for the bottle again. 
Zoloft is meant to relieve depression, anxiety and other symptoms of serotonin imbalance.When Zoloft and alcohol confront each other in the brain, the negation of each other's impact on someone's behavior and thoughts struggles to occur with possibly unfavorable results.
While
Zoloft wants to elevate your mood, alcohol wants to bring it down. This unhealthy interaction could create extreme behaviors resulting in physical injury. 

If you are feeling lost or confused, this would be an appropriate concern to talk to your prescribing doctor about. Think about the known potential side effects from taking Zoloft, combined with the known impacts that alcohol has on our brain and behavior.
One could assume that combining the two would potentially compound and/or enhance the side effects of the other.  

Zoloft, as well as other antidepressants, should never be discontinued because someone feels the need to drink. Abruptly stopping Zoloft usually causes depression and anxiety to worsen. Obsessive compulsive behavior will become more rigid as well. 

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